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目的确定穿透性角膜移植术椭圆形植片在新西兰白兔角膜白斑模型上降低散光的作用。方法 24只新西兰成年白兔随机取一眼制作角膜灼伤横椭圆白斑模型。稳定一月后,测白斑直径、行角膜地形图检查。随机取12只作为对照组,行圆形穿透性角膜移植术,余下作为实验组,行椭圆形植片穿透性角膜移植术。术后3月,透明植片测角膜地形图。结果角膜白斑模型的直径测量与预设计值的差异无统计学意义(P>0.05)。术后角膜地形图分析:二组的表面规则性指数(Surface Regularity Index,SRI)值和表面非对称性指数(Surface Asymmetry Index SAI)值相比差别无统计学意义(P>0.05);实验组的散光度数为4.75±0.047D,对照组的散光度数为8.45±0.59D,二者相比差别有极显著的统计学意义(P<0.001),且实验组低于对照组2.70±0.76D。结论对于横椭圆形角膜白斑的穿透性角膜移植术,椭圆形植片较圆形植片有效地降低术后的散光。
Objective To determine the role of penetrating keratoplasty oval grafts in reducing asthma on a New Zealand White Rabbit corneal leukoplakia model. Methods Twenty-four adult New Zealand white rabbits were randomly selected to make a corneal horizontal scalp injury model. After stabilizing in January, measure the white spot diameter, check corneal topography. Twelve randomly selected as the control group, underwent round penetrating keratoplasty, the remaining as the experimental group, oval implant penetrating keratoplasty. 3 months after surgery, transparent grafts measured corneal topography. Results There was no significant difference between the diameter of corneal leukoplakia and the pre-design value (P> 0.05). Postoperative corneal topography analysis: There was no significant difference in Surface Regularity Index (SRI) and Surface Asymmetry Index (SAI) between the two groups (P> 0.05) The astigmatism degree was 4.75 ± 0.047D, while that of the control group was 8.45 ± 0.59D. The difference between the two groups was statistically significant (P <0.001), and the experimental group was 2.70 ± 0.76D lower than the control group. Conclusions For penetrating keratoplasty with transverse oval corneal leukoplakia, oval grafts are more effective in reducing postoperative astigmatism than circular grafts.