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目的:探讨IL-33及其可溶型受体ST2(sST2)与原发性干燥综合征(pSS)的关系。方法:pSS患者110例,其中54例合并间质性肺病(ILD),17例合并自身免疫性甲状腺疾病(AITD),28例合并自身免疫性肝病(AIHD),41例合并肾小管酸中毒(RTA)。通过ELISA方法测定110例pSS患者及45例健康对照组中IL-33和sST2的血清浓度水平。同时记录pSS患者血清学的各项指标及脏器受累情况。并对IL-33及sST2的血清水平与患者各项血清学指标和脏器受累情况进行分析。结果:血清IL-33的水平在pSS患者明显增高,与健康对照组比较有显著性差异(P<0.01)。并且,血清IL-33的水平在pSS合并有ILD组及AITD组明显升高(P<0.05)。血清IL-33水平与类风湿因子水平成正相关(P<0.01),血清sST2水平与IgA成正相关(P<0.05),而血清sST2水平和血红蛋白则成负相关(P<0.01)。结论:血清IL-33的水平在pSS患者中明显升高,可能参与了pSS的脏器损伤。
Objective: To investigate the relationship between IL-33 and its soluble receptor ST2 (sST2) and primary Sjogren’s syndrome (pSS). Methods: A total of 110 patients with pSS were enrolled in this study. 54 patients with interstitial lung disease (ILD), 17 with autoimmune thyroid disease (AITD), 28 with autoimmune liver disease (AIHD) and 41 with tubular acidosis RTA). Serum levels of IL-33 and sST2 in 110 pSS patients and 45 healthy controls were determined by ELISA. At the same time, the indexes of serology and organ involvement in pSS patients were recorded. Serum levels of IL-33 and sST2 were also analyzed in relation to various serological markers and organ involvement. Results: The level of serum IL-33 in pSS patients was significantly higher than that in healthy controls (P <0.01). Moreover, the level of serum IL-33 was significantly increased in pSS with ILD and AITD (P <0.05). Serum IL-33 level was positively correlated with rheumatoid factor (P <0.01). Serum sST2 level was positively correlated with IgA (P <0.05), while serum sST2 level was negatively correlated with hemoglobin (P <0.01). Conclusion: The level of serum IL-33 is significantly increased in patients with pSS, which may be involved in the injury of pSS.