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通过比较30例经抗癫痫治疗无效或效差患儿与59例显效患儿的8项免疫学指标发现,治疗无效或效差组血清IgG,IgM,IgA(女性)平均含量及E玫瑰花环形成率均显著低于显效组(P<0.05),补体C_3水平显著高于显效组(P<0.05).上述变化与患儿年龄、临床发作类型、病程及疗程等因素无关.从而提示免疫功能低下不仅是癫痫患者自稳机制紊乱的表现,而且也是影响疗效的重要因素,改善免疫功能可能是提高抗癫痫治疗效果的有效途径之一.
By comparing 30 immunosuppressive measures in children with or without effective treatment of epilepsy and 59 effective children, the average levels of serum IgG, IgM and IgA (female) and E-rosette formation (P <0.05), and the level of complement C_3 was significantly higher than that in the effective group (P <0.05) .The above changes were not related to the children’s age, type of clinical attack, duration of disease and course of treatment, which suggested that the immunocompromised It is not only the manifestation of disorder of self-stabilization in patients with epilepsy, but also an important factor affecting the curative effect. Improving immune function may be one of the effective ways to improve antiepileptic effect.