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本文测定32例正常人和34例应用克糖利(Glutril)治疗的非胰岛素依赖型糖尿病患者的 GHb 和 GSP 浓度。治疗前34例病人 GHb、GSP 及空腹血糖(FBG)值明显高于正常组(P<0.01)。治疗3～6个月后,31例病人(91.2%)GHb、GSP 降至正常,21例病人(61.8%)FBG 降至正常,10例病人(29.4%)FBG 接近正常(116～145 mg/d 1)。疗效差的3例病人(8.8%)GHb、GSP 和 FBG 水平治疗前后无明显变化。据此提出 GHb、GSP 可做为评价糖尿病控制的一项较客观有用的生化指标。
This article measured the GHb and GSP concentrations in 32 normal subjects and 34 non-insulin dependent diabetic patients treated with Glutril. The GHb, GSP and fasting blood glucose (FBG) values of the 34 patients before treatment were significantly higher than those of the normal group (P <0.01). After 3 to 6 months of treatment, FBG in 21 patients (61.8%) dropped to normal in 31 patients (91.2%), FBG in 10 patients (29.4%) approached normal (116- 145 mg / d 1). Three patients with poor efficacy (8.8%) had no significant changes in GHb, GSP and FBG levels before and after treatment. Accordingly proposed GHb, GSP can be used as a more objective and useful biochemical indicators of diabetes control.