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应用硝酸还原酶法检测了 31例慢性肾功不全患者及 2 6例血液透析( HD)患者血透过程中血清一氧化氮 ( s- NO)水平的变化。结果表明 :慢性肾衰患者 s-NO水平明显升高 ( P <0 .0 0 1 ) ;合并高血压组 s- NO水平低于无高血压组 ( P <0 .0 5 ) ;HD过程中 s- NO浓度逐渐下降 ,HD2 h、HD4h与透析前比较差别显著 ( P <0 .0 0 1 ) ;透析过程中血压升高与 s- NO下降有一定关系。结论 :慢性肾功衰竭患者 s-NO水平升高可能与肾功能明显减退有关 ;HD能清除硝酸盐 ,透析中 s- NO下降可能是导致透析中血压升高的原因之一。
Nitric acid reductase method was used to detect changes of serum nitric oxide (s-NO) level in 31 patients with chronic renal failure and 26 patients with hemodialysis (HD). The results showed that the levels of s-NO in patients with chronic renal failure were significantly increased (P <0.01); the levels of s-NO in patients with hypertension were lower than those without hypertension (P <0.05); HD The concentration of s-NO gradually decreased, while the HD2h and HD4h were significantly different from that before dialysis (P <0.01). There was a relationship between the increase of blood pressure and the decrease of s-NO during dialysis. CONCLUSIONS: Elevated s-NO level in patients with chronic renal failure may be related to the marked decline of renal function. HD can remove nitrate, and the decrease of s-NO in dialysis may be one of the reasons leading to the increase of blood pressure during dialysis.