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It has been well established that eytotoxic T lymphocytes(CTLs)are responsible for the mediation of host immune response against immunogenic tumors.However,their effective use in cancer immunotherapy is hampered because T cell activation requires co-stimulatory signals,such as ligands for CD28 besides T-cell receptor(TCR) occupancy.Unfortunately,many malignant tumors of epithelial origin do not express ligands for CD28.Two groups
It has been well established that eototoxic T lymphocytes (CTLs) are responsible for the mediation of host immune response against immunogenic tumors. However, their effective use in cancer immunotherapy is hampered because T cell activation requires co-stimulatory signals, such as ligands for CD28 besides T-cell receptor (TCR) occupancy. Unfortunately, many malignant tumors of epithelial origin do not express ligands for CD28.Two groups