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系统性红斑狼疮(SLE)是一周身性自身免疫性疾病。全身各脏器均可被侵及,临床表现多样,血清中有多种自身抗体及较大量免疫复合物存在。SLE的发病机制虽已有所了解,但是病因至今尚未完全阐明。所以,治疗非常棘手,死亡率高。1970年起甾体类药物(激素)应用于临床后,SLE的预后有了明显的改善。以后随着激素新剂型的不断出现,以及非甾体类药物及其他免疫抑制剂合并应用,使SLE存活率更有所提高。
SLE is a systemic autoimmune disease. Various organs of the body can be invading, clinical manifestations of diverse serum autoantibodies and a large number of immune complexes exist. Although the pathogenesis of SLE has been understood, but the etiology has not yet been fully elucidated. Therefore, the treatment is very difficult, high mortality. Since 1970 steroidal drugs (hormones) used in clinical, the prognosis of SLE has been significantly improved. Later with the continuous emergence of new hormone forms, and non-steroidal drugs and other immunosuppressive agents combined application, so that SLE survival rate increased even more.