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60年代有作者推测阿扑吗啡对多巴胺能受体有直接激动作用,随后又有作者证实,阿扑吗啡与多巴胺和苯丙胺相似,均可使动物发生刻板动作,并能减少黑质神经元内的放电频率,降低血内催乳素水平。因此,有关阿扑吗啡直接激动多巴胺能受体的观点,目前已被大多数学者所公认。晚近某些作者认为,多巴胺缺损是帕金森氏综合征的病理生化基础,而阿扑吗啡具有抗帕金森氏综合征的作用,Ernst(1969)报告,一次或多次
In the 1960s, some authors speculate that apomorphine has a direct agonistic effect on dopaminergic receptors. Subsequently, another author confirmed that apomorphine, which is similar to dopamine and amphetamine, can cause animals to undergo a stereotypical action and reduce the number of neurons in the substantia nigra neurons Discharge frequency, lower blood prolactin levels. Therefore, the view that apomorphine directly activates dopaminergic receptors has been recognized by most scholars at present. Some recent authors believe that dopamine deficiency is the pathophysiology of Parkinson’s disease and that apomorphine has anti-Parkinsonism effects. Ernst (1969) reported one or more