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目的:研究香枳和胃片对小鼠胃排空、肠推进活动的调节作用。方法:采用酚红为标记物,测定小鼠的胃内色素残留量观察香枳和胃片对小鼠胃排空的影响,采用小肠炭末推进实验观察其对小肠运动的影响。结果:香枳和胃片对小鼠的胃排空、小肠推进均具有一定的促进作用,并且有一定的剂量依赖性,尤其是高剂量组药效与空白对照组相比,具有非常显著的统计学意义(P<0.01)。高剂量组对小肠的促动力效应与阳性对照西沙比利组比较无显著性差异(P>0.05)。结论:香枳和胃片对小鼠的胃肠运动均有促进作用,高剂量组治疗效果更显著。
Objective: To study the regulation effect of Xiang-tai and stomach tablet on gastric emptying and intestinal propulsion in mice. Methods: Phenol red was used as a marker to determine the amount of residual pigment in the stomach of mice. The effects of Xiang-tai and stomach tablet on gastric emptying in mice were observed. The effect of small intestine on the intestinal motility was observed by propulsion of carbon powder. Results: Xiang-tai and stomach tablet can promote gastric emptying and small intestine in mice and dose-dependently, especially in the high-dose group. Compared with the blank control group, Statistical significance (P <0.01). The effect of high dose on small intestine was not significantly different from that of cisapride (P> 0.05). CONCLUSION: Fragrant trifoliate orange juice and stomach tablet can promote the gastrointestinal motility of mice, while the treatment effect of high dose group is more obvious.