论文部分内容阅读
目的:观察通泰胶囊灌胃给药后对前列腺炎大鼠的治疗作用,为临床应用提供药效学依据。方法:采用大鼠前列腺背叶注入消痔灵注射液的方法造成前列腺炎模型。各鼠按体重灌胃通泰胶囊,连续30天,末次给药1h后,取血分离血清测SOD,MDA,GSH-Px酶活力,脱臼处死,取前列腺称重,再以10%福尔马林固定,HE染色,作组织病理学检查。结果:通泰胶囊能明显降低前列腺炎大鼠的前列腺湿重和前列腺指数,改善前列腺炎大鼠的炎性浸润,并可提高大鼠体内抗氧化酶活性,降低体内脂质过氧化反应,提高机体清除自由基的能力,具有调节和改善机体氧自由基代谢失衡的作用。病理检查结果也显示通泰胶囊能明显改善模型大鼠前列腺的炎性病理改变。结论:通泰胶囊对前列腺炎模型大鼠有很好的治疗作用。
OBJECTIVE: To observe the therapeutic effect of Tongtai Capsules on rats with prostatitis after intragastric administration, and to provide pharmacodynamic basis for clinical application. METHODS: The prostatitis model was induced by injecting Xiaozhiling injection into the back of the prostate in rats. Rats were given Tongtai capsules by body weight for 30 consecutive days. After the last administration for 1 hour, blood was taken to measure SOD, MDA, and GSH-Px enzyme activity, and they were sacrificed after deodorization. The prostate was weighed and 10% formalin was weighed. Fixed, HE stained for histopathological examination. Results: Tongtai capsule can significantly reduce the prostatitis wet weight and prostate index in rats with prostatitis, improve inflammatory infiltration in rats with prostatitis, increase antioxidant enzyme activity in rats, reduce lipid peroxidation in vivo, and increase body weight. The ability to scavenge free radicals has the effect of regulating and improving the imbalance of oxygen free radical metabolism in the body. Pathological examination also showed that Tongtai capsule can significantly improve the inflammatory pathological changes in the prostate of model rats. Conclusion: Tongtai capsule has a good therapeutic effect on prostatitis model rats.