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目的观察肥胖患者空腹血清脑肠肽水平的变化与胰岛素抵抗的关系。方法放射免疫法测定33例肥胖患者(肥胖组)和26例健康体检者(对照组)血清脑肠肽水平,分析其与体重指数(BMI)、空腹血糖(FBG)、空腹胰岛素(FIns)、胰岛素抵抗指数(HOMA-IR)的关系。结果肥胖组空腹血清脑肠肽(910±136)ng/L,明显低于对照组的(1150±215)ng/L(P<0.01);肥胖组空腹血清脑肠肽水平与HOMA-IR、BMI呈负相关,与胰岛素敏感性指数(ISI)呈正相关;多元线性逐步回归分析显示,HOMA-IR可能是影响血清脑肠肽水平的独立相关因素。结论肥胖患者空腹血清脑肠肽水平下降,提示HOMA-IR可能对血清脑肠肽水平存在影响。
Objective To observe the relationship between fasting serum brain gut peptide and insulin resistance in obese patients. Methods Serum ghrelin levels were determined by radioimmunoassay in 33 obese patients (obesity group) and 26 healthy controls (control group). The levels of serum ghrelin, body mass index (BMI), fasting blood glucose (FBG), fasting insulin (FIns) Insulin Resistance Index (HOMA-IR) relationship. Results The fasting serum brain-gut peptide (910 ± 136) ng / L in obesity group was significantly lower than that in control group (1150 ± 215) ng / L (P <0.01) BMI was negatively correlated with insulin sensitivity index (ISI). Multiple linear stepwise regression analysis showed that HOMA-IR might be an independent factor influencing serum brain-gut peptide level. Conclusion The decrease of fasting serum brain gut peptide in obese patients suggests that HOMA-IR may affect the level of serum brain gut peptide.