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目的:研究补肾化痰方对多囊卵巢综合征模型鼠血清瘦素(Leptin)水平的影响。方法:采用孕激素和HCG联合造模法制备多囊卵巢综合征大鼠模型,研究各用药组及正常对照组体重及瘦素水平的差异。结果:与正常对照组比较,模型对照组体重及Leptin均增加(P<0.05);用药各组均能降低体重及Leptin水平,其中高剂量组、阳性对照组及联合用药组Leptin降低明显,与正常对照组比较无显著性差异(P>0.05);Leptin与体重成正相关,r值为0.401。结论:降低瘦素水平,提高瘦素的生物学效应,减轻体重,可能是补肾化痰方治疗PCOS的药理机制之一。
Objective: To study the effect of Bushen Huatan Fang on serum leptin level in polycystic ovary syndrome model rats. Methods: Polycystic ovary syndrome rat model was prepared by combination of progesterone and HCG, and the difference of body weight and leptin level between each drug group and normal control group was studied. Results: Compared with the normal control group, body weight and Leptin increased (P <0.05) in the model control group. The body weight and Leptin level of the model control group decreased significantly. Leptin in the high dose group, positive control group and combination group decreased significantly, There was no significant difference in normal control group (P> 0.05). Leptin was positively correlated with body weight, r value was 0.401. CONCLUSION: It is one of the pharmacological mechanisms of Bushen Huatan Fang to treat PCOS by reducing the leptin level, improving the biological effect of leptin and reducing body weight.