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本文采用系统的血液流变学研究方法,观察了245例各期高血压患者的血液流变学改变,同时观察其甲皱微循环和血脂的变化,并与116例正常人作对照。结果表明:高血压患者存在着显著的血液高粘滞状态,表现为全血粘度、血浆粘度和全血还原粘度均明显升高(P<0.001)。这种改变在高血压Ⅰ期即已存在,随着病情发展而加重。同时伴有HCT、EER及红细胞变形能力的明显异常(P<0.01)各期高血压患者均出现明显的甲皱微循环障碍,主要表现为毛细血管袢的严重畸型及其内血流速度缓慢。本结果证实了高血压病理过程中存在着血液流变学异常及微循环障碍。这种改变与病情发展有关。提示其对高血压病理过程的影响。
In this study, a systematic study of hemorheology was performed to observe the changes of hemorheology in 245 patients with various stages of hypertension, and to observe the changes of microcirculation and blood lipids in nail fold and to compare with 116 healthy controls. The results showed that there was significant hyperviscosity of blood in hypertensive patients, which showed that whole blood viscosity, plasma viscosity and whole blood reduced viscosity were significantly increased (P <0.001). This change in the first phase of hypertension already exists, with the progression of the disease worsened. Accompanied by significant abnormalities of HCT, EER and erythrocyte deformability (P <0.01). All patients with hypertension showed obvious nail-fold microcirculation disturbance, which was mainly manifested as severe deformity and slow blood flow in capillaries. This result confirms the existence of abnormal blood rheology and microcirculation disorder in the pathological process of hypertension. This change and the development of the disease. Suggesting its impact on the pathological process of hypertension.