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目的观察蒲地蓝佐治复发性口腔溃疡(ROU)及糜烂型口腔扁平苔藓(e OLP)的短期疗效。方法将ROU和e OLP患者180例按照奇偶数字分组法分成A、B、C 3组,各60例。A组行局部外用喷剂联合中成药蒲地蓝消炎口服液治疗,B组行单纯西药局部治疗,C组行蒲地蓝消炎口服液治疗。治疗后,对比观察3组临床症状的改善程度,比较短期疗效。结果 A组用药后1周ROU及e OLP患者治疗的总有效率均明显高于B组和C组,差异均有统计学意义(P<0.05)。3组ROU患者用药后2周总有效率差异无统计学意义(P>0.05)。A组、C组e OLP患者用药2周后总有效率均高于B组,差异有统计学意义(P<0.05)。A组与C组e OLP患者治疗总有效率比较差异无统计学意义(P>0.05)。结论常规局部外用喷剂联合蒲地蓝治疗ROU及e OLP可促进患者病情的缓解,提高短期疗效,值得推广应用。
Objective To observe the short-term efficacy of puerarin in treating recurrent oral ulcer (ROU) and erosive oral lichen planus (OLP). Methods One hundred and eighty patients with ROU and e OLP were divided into A, B and C groups according to the even and odd number grouping method, 60 cases each. A group of local topical spray combined with Chinese medicine Po Di Lan anti-inflammatory oral liquid treatment, B group of simple western medicine local treatment, C group of Pu Di Lan anti-inflammatory oral liquid treatment. After treatment, compared to observe the improvement of clinical symptoms in 3 groups, compare short-term efficacy. Results The total effective rate of treatment of ROU and e OLP in group A after 1 week of treatment was significantly higher than that in group B and C (P <0.05). There was no significant difference in the total effective rate between the two groups after 3 weeks of treatment (P> 0.05). The total effective rate of group A and group C e OLP patients after two weeks of treatment was significantly higher than that of group B (P <0.05). There was no significant difference in total effective rate between group A and group C (P> 0.05). Conclusion Conventional topical topical sprays combined with povidone in the treatment of ROU and e OLP can promote the alleviation of patients’ condition and improve the short-term curative effect, which deserved to be popularized and applied.