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目的探讨262例肺结核患者痰培养阳性菌株对十种抗结核药物的耐药性。并对耐INH、RFP、SM及HR者等进行了敏感药物的选择。方法全部痰培养阳性标本由实验室作药敏测定,并对敏感药物进行治疗效果观察。结果 262株分支杆菌耐单药顺位次序为:RFP40.8%、SM36.6%、INH38.9%、1321TH20.8%、EMB10.7%、PAS7.6%、KM6.9%、DiP5.7%、CPM4.3%、OFLX4.3%。对耐HR64例患者治疗中应用DiP、OFLX、CPM方案,6个月痰菌阴转率达79.7%。结论我市属于高耐药区域,以耐RFP、SM、INH者居前三位。DiP、OFLX、CPM对耐HR者有疗效。
Objective To investigate the resistance of sputum culture positive strains to ten kinds of anti-tuberculosis drugs in 262 pulmonary tuberculosis patients. And resistant to INH, RFP, SM and HR who were sensitive to drug selection. Methods All sputum culture positive samples were determined by the laboratory for drug susceptibility, and the treatment of sensitive drugs was observed. Results The order of single drug resistance to Mycobacterium tuberculosis was RFP40.8%, SM36.6%, INH38.9%, 1321TH20.8%, EMB10.7%, PAS7.6%, KM6.9%, DiP5. 7%, CPM4.3%, OFLX4.3%. DiP, OFLX, and CPM regimens were used in the treatment of HR64-resistant patients and the sputum negative conversion rate was 79.7% at 6 months. Conclusion The city belongs to the high resistance area, with the resistance of RFP, SM, INH among the top three. DiP, OFLX, CPM is effective against HR.