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目的:研究血清糖链抗原(CA724)和糖链抗原(CA50)在胃癌患者手术前后的水平变化及临床意义。方法:胃癌患者33例,良性胃疾病患者31例,在33例胃癌患者中有6例复发转移,采用免疫放射分析法(IRMA)分别检测了空腹血清CA724和CA50水平。结果:胃癌组血清CA724和CA50水平分别为21.7±44.6U/ml,27.8±37.5U/ml,胃良性疾病组血清CA724和CA50水平分别为2.98±1.64U/ml,6.78±7.45U/ml,差异显著(P<0.01)。胃癌患者术前组血清CA724、CA50水平分别为21.7±44.6U/ml,27.8±37.5U/ml高于术后14.3±26.6U/ml,22.5±31.4U/ml,差异显著(P<0.01)和(P<0.05)。胃癌患者有淋巴结转移组血清CA724、CA50水平分别为27.3±64.5U/ml,30.6±48.8U/ml,高于无淋巴结转移组17.4±30.8U/ml,19.9±27.3U/ml,差异显著(P<0.01)。结论:手术切除肿瘤特别是行根治性切除术后,血清CA724水平显著降低。动态观察CA724、CA50水平及其变化,表明CA724、CA50水平与肿瘤的浸润及转移过程密切相关,胃癌患者手术前后的测定对有无复发转移是一项重要的判断指标。
Objective: To study the changes and clinical significance of serum carbohydrate antigen (CA724) and carbohydrate antigen (CA50) in patients with gastric cancer before and after operation. Methods: 33 cases of gastric cancer, 31 cases of benign gastric diseases, and 6 cases of 33 cases of gastric cancer recurrence and metastasis. The levels of fasting serum CA724 and CA50 were detected by immunohistochemical method (IRMA). Results: The levels of CA724 and CA50 in gastric cancer group were 21.7 ± 44.6U / ml and 27.8 ± 37.5U / ml, respectively. The levels of CA724 and CA50 in gastric benign disease group were 2.98 ± 1.64U / ml and 6.78 ± 7.45U / ml respectively, The difference was significant (P <0.01). The levels of serum CA724 and CA50 in preoperative group were 21.7 ± 44.6U / ml and 27.8 ± 37.5U / ml respectively, which were significantly higher than those in 14.3 ± 26.6U / ml and 22.5 ± 31.4U / ml postoperatively (P <0.01) And (P <0.05). The serum levels of CA724 and CA50 in patients with lymph node metastasis were 27.3 ± 64.5U / ml and 30.6 ± 48.8U / ml, respectively, which were significantly higher than those in patients without lymph node metastasis (17.4 ± 30.8U / ml, 19.9 ± 27.3U / ml) P <0.01). CONCLUSIONS: Serum CA724 levels are significantly reduced after surgical excision of the tumor, especially after radical resection. Dynamic observation of CA724, CA50 levels and changes, indicating that CA724, CA50 levels and tumor invasion and metastasis are closely related to the determination of gastric cancer patients with or without recurrence and metastasis is an important indicator.