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胎儿宫内生长受限是心血管疾病一个独立的危险因素,与儿童期动脉内膜厚度相关,目前未发现相应的预防策略。本研究试图探讨儿童早期膳食补充ω-3脂肪酸能否阻止胎儿宫内生长受限与儿童期动脉内膜厚度间的关联。采用随机对照单盲试验,选取616个足月儿,随机分为两组,一组每天补充500 mg的鱼油(ω-3脂肪酸组),另一组每天补充500 mg的向日葵油(对照组),从出生后6个月直到5岁,8岁时测量两组儿童的颈动脉内膜厚度,在出生体重小于P90的两组儿童中,
Fetal intrauterine growth restriction is an independent risk factor for cardiovascular disease, which is related to the thickness of arterial intima in children. So far, no corresponding prevention strategy has been found. This study sought to investigate whether early dietary supplementation of omega-3 fatty acids in children may prevent the association between fetal intrauterine growth restriction and childhood arterial intima-media thickness. A single-blind randomized controlled trial of 616 full-term infants was randomly divided into two groups: one group supplemented daily with 500 mg fish oil (omega-3 fatty acid group), and the other group supplemented with 500 mg daily sunflower oil (control group) , From 6 months after birth until 5 years old, at the age of 8, the carotid intima-media thickness of the two groups of children was measured. Among the two groups of children whose birth weight was less than P90,