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近来肝脏外科注意到了接受肝脏治愈性切除的肝癌患者的营养状况。绝大部分的肝癌患者伴有肝硬化,而且必需在营养状况不理想时接受肝切除手术。肝硬化被认为是处于一个过度分解代谢的“蛋白质营养不良”期。而应用支链氨基酸可以纠正这种“营养不良”。研究旨在阐明,对于那些接受肝切除的原发性肝癌患者,长期口服支链氨基酸对于临床症状、实验室指标、癌肿的复发和提高生存率等方面的影响。 方法:在手术后2～3周内,75位患者被随机列为接受口服支链氨基酸,每天100g,共1
Hepatic surgery recently noted the nutritional status of liver cancer patients undergoing hepatic resection. The vast majority of liver cancer patients have cirrhosis and must undergo liver resection when their nutritional status is unsatisfactory. Cirrhosis is thought to be in a period of “protein malnutrition” that is an over-catabolism. The use of branched-chain amino acids can correct this “malnutrition.” The aim of the study was to clarify the effect of long-term oral branched-chain amino acids on clinical symptoms, laboratory parameters, recurrence of cancer, and improved survival in patients with primary liver cancer undergoing hepatectomy. METHODS: Within 2 to 3 weeks after surgery, 75 patients were randomly assigned to receive oral branched-chain amino acids, 100 g daily for a total of 1