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目的研究大接骨丹Torricellia angulata var.intermedia根皮的化学成分。方法采用硅胶、大孔树脂、Sephadex LH-20和ODS等色谱手段进行化学成分的分离纯化;依据理化性质、波谱数据和相关文献进行结构鉴定。结果分离鉴定了10个化合物,分别鉴定为丁香树脂酚(1)、豆甾醇(2)、3,4,5,7-四羟基-苯乙酸(3)、豆甾-5,11-二烯-3β-醇(4)、22,23-二氢豆甾醇(5)、β-胡萝卜苷(6)、26,27-dinor-4,4-dimethyl-cholesta-8,14-dien-3-ol(7)、硬脂酸(8)、软脂酸(9)、4-羟基-3,5-二甲氧基苯甲醛(10)。结论其中化合物3为新的天然产物,化合物1、2、4、5、7、10为首次从该植物中分离得到。
Objective To study the chemical composition of the root bark of Torricellia angulata var.intermedia. Methods Silica gel, macroporous resin, Sephadex LH-20 and ODS were used to separate and purify the chemical constituents. The structures were elucidated on the basis of physico-chemical properties, spectral data and related literature. Results Ten compounds were isolated and identified as syringylphenol (1), stigmasterol (2), 3,4,5,7-tetrahydroxy-phenylacetic acid (3) -3,4-dimethyl-cholesta-8,14-dien-3- (4), 22,23-dihydrosditerol (5) ol (7), stearic acid (8), palmitic acid (9), 4-hydroxy-3,5-dimethoxybenzaldehyde (10). Conclusions Among them, compound 3 is a new natural product. Compounds 1, 2, 4, 5, 7 and 10 were isolated from this plant for the first time.