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选用４０只雄性Ｗｉｓｔａｒ大鼠，随机分成环氧丙烷（ＰＯ）染毒组与对照组，采用静式吸入染毒，以５档计算浓度分别为３００，５００，１０００，２０００，５０００ｍｇ／ｍ３，对实验组大鼠每次染毒２小时，染毒结束后，立即测定闪光视觉诱发电位（ＦＥＰ）和模式翻转视觉诱发电位（ＰＲＥＰ），分析各波（Ｐ１、Ｎ１、Ｐ２，Ｎ２和Ｎ１、Ｐ１、Ｎ２）潜伏期及其波幅（Ｎ１－Ｐ２、Ｐ２－Ｎ２和Ｎ１－Ｐ１、Ｐ１－Ｎ２）。大鼠在２０００ｍｇ／ｍ３染毒时，ＰＲＥＰ测定中Ｎ２波潜伏期显著延长。５０００ｍｇ／ｍ３浓度时，ＰＲＥＰ和ＦＥＰ各波潜伏期均有显著延长，于第２天已部分恢复，但波幅未见改变。这说明ＰＯ对中枢神经系统产生功能性抑制作用。然而低浓度ＰＯ染毒时就出现呼吸道刺激症状，远早于诱发电位的变化；高浓度时有明显呼吸系统刺激症状，出现呼吸困难。因此，急性ＰＯ染毒对中枢神经的抑制作用较小，主要为呼吸系统刺激作用
Forty male Wistar rats were randomly divided into three groups: PO group and control group. The animals were exposed to inhalation aerosol. Concentrations of 300, 500, 1000, 2000 and 5000 mg / Rats in the experimental group were exposed to 2 hours of each exposure. Immediately after the exposure, flash visual evoked potentials (FEP) and mode-switched visual evoked potentials (PREP) were measured. The effects of various waves (P1, N1, P2, N2 and N1, P1 , N2) latency and its amplitude (N1-P2, P2-N2 and N1-P1, P1-N2). When the rat was exposed to 2000mg / m3, the incubation period of N2 wave in PREP was significantly prolonged. At the concentration of 5000mg / m3, the latency of each wave of PREP and FEP was significantly prolonged, partially recovered on the second day, but the amplitude was unchanged. This shows that PO has a functional inhibitory effect on the central nervous system. However, low concentrations of PO poisoning appeared respiratory irritation symptoms, long before the changes in evoked potentials; high concentrations of respiratory irritation was obvious symptoms appear breathing difficulties. Therefore, the acute PO poisoning on the central nervous inhibitory effect is small, mainly for respiratory stimulation