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目的 :观察颈部迷走神经干电刺激对癫大鼠行为及额叶、海马、杏仁核脑区放电的影响 ,为迷走神经刺激 (VagusNerveStimulation ,VNS)抑机制研究提供理论依据。方法 :利用脑立体定位手段 ,将电极埋入大鼠脑部双侧额叶皮质、海马和杏仁核 ,记录VNS前后由红藻氨酸 (KA)诱发复杂部分性癫大鼠脑电变化并观察动物行为的改变。结果 :VNS后大鼠癫强直 阵挛发作次数明显减少 ,首次发作潜伏期延长 ,癫发作平均持续时间缩短 ;VNS尤其对杏仁核放电有明显的抑制作用。结论 :VNS能有效抑制KA诱发的复杂部分性癫发作 ,并且杏仁核可能是抑作用的关键核团
Objective: To observe the effects of cervical vagal nerve stimulation on the behavior of epileptic rats and the discharge in the frontal lobe, hippocampus and amygdala, and to provide a theoretical basis for the study on the mechanism of vagus nerve stimulation (VNS) inhibition. Methods: Electrodes were embedded in the bilateral frontal cortex, hippocampus and amygdala by brain stereotactic method. The changes of electroencephalogram of complex partial epilepsy rats induced by kainate (KA) before and after VNS were recorded. Observe changes in animal behavior. Results: The number of epileptic tonic clonic seizures decreased significantly after VNS. The latency of first seizure was prolonged and the average duration of epileptic seizures was shortened. VNS especially inhibited the discharge of amygdala. Conclusion: VNS can effectively inhibit KA-induced complex partial epileptic seizures, and the amygdala may be the key nucleus of inhibition