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目的探讨特布他林联合布地奈德治疗小儿中度慢性持续支气管哮喘的临床效果。方法选取广东医学院附属南山医院儿科收治的小儿中度慢性支气管哮喘患者60例,随机分为试验组与对照组,每组30例。对照组给予药物布地奈德喷雾吸入治疗,试验组给予特布他林联合布地奈德喷雾吸入治疗。比较2组患者临床疗效、临床症状消失时间以及不良反应发生率,并于1个月后对患者的康复程度进行观察。结果试验组患者临床改善程度较对照组显著提高,且试验组患者的总有效率高于对照组,2组相比差异有统计意义(P<0.05),1个月后对患者随访,试验组患者的总有效率高于对照组患者,差异有统计学意义(P<0.05)。试验组患者出现鼻出血2例、皮炎1例;对照组患者出现鼻出血1例,皮炎1例,鼻黏膜溃疡1例。2组患者在停药后不良反应症状均消失。结论特布他林联合布地奈德治疗小儿中度慢性持续支气管哮喘效果显著,不良反应小。
Objective To investigate the clinical efficacy of terbutaline combined with budesonide in the treatment of children with moderate chronic bronchial asthma. Methods Sixty children with moderate chronic bronchial asthma admitted to Nanshan Hospital affiliated to Guangdong Medical College were randomly divided into experimental group and control group with 30 cases in each group. The control group was treated with budesonide spray inhalation, and the test group was given terbutaline combined with budesonide spray inhalation. The clinical efficacy, the disappearance of clinical symptoms and the incidence of adverse reactions in the two groups were compared. The degree of recovery of the patients was observed after one month. Results The clinical improvement rate of the experimental group was significantly higher than that of the control group, and the total effective rate of the experimental group was higher than that of the control group (P <0.05). After 1 month, the patients were followed up. The experimental group The total effective rate of patients was higher than that of the control group, the difference was statistically significant (P <0.05). There were 2 cases of nosebleed and 1 case of dermatitis in the test group, 1 case of nosebleed, 1 case of dermatitis and 1 case of nasal ulcer in the control group. Two groups of patients after stopping the adverse reaction symptoms disappeared. Conclusion Terbutaline combined with budesonide in children with moderate chronic persistent bronchial asthma significant effect with little adverse reactions.