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随机选择 1 0 0例 2型糖尿病患者 ,按有无视网膜病变 (DR)分组 ,检测他们的血脂、脂蛋白、糖基化血红蛋白、胰岛素水平。结果 :有DR组与无DR组比较血清总胆固醇 (Tch)、低密度脂蛋白 (LDL -C) ,载脂蛋白B(APOB)明显增高 (P <0 0 5 ) ,甘油三酯 (TG) (P <0 0 1 ) ,血高密度脂蛋白 (HDL -C)、载脂蛋白A(APOA)明显下降(P <0 0 5 )。增殖期DR组与单纯期DR组比较 ,TG 显著增高 (P <0 0 1 ) ,胰岛素抵抗指数有显著差异 (P <0 0 1 )。结论 :血脂代谢异常及胰岛素抵抗 ,影响着DR的发生发展。因此 ,糖尿病患者应严格控制血糖、血脂水平。
One hundred and ten patients with type 2 diabetes mellitus were randomly selected and their serum lipids, lipoproteins, glycosylated hemoglobin and insulin levels were measured according to the presence or absence of retinopathy (DR). Results: Serum levels of total cholesterol (Tch), low density lipoprotein (LDL-C) and apolipoprotein B (APOB) were significantly increased in DR group compared with no DR group (P <0.01), blood HDL-C and APOA decreased significantly (P <0.05). Compared with simple DR group, the proliferative phase DR group showed significantly higher TG (P <0.01) and insulin resistance index (P <0.01). Conclusion: Abnormal lipid metabolism and insulin resistance affect the occurrence and development of DR. Therefore, patients with diabetes should be strictly controlled blood glucose, blood lipid levels.