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目的探讨护理干预对奥沙利铂联合卡培他滨治疗结肠癌患者不良反应的影响。方法选取2015年1月至2016年1月间大连大学附属中山医院收治的90例结肠癌患者,采用随机数字表法分为观察组(护理干预)和对照组(常规护理),每组45例,两组患者均给予奥沙利铂联合卡培他滨化疗。比较两组患者护理后的临床疗效与化疗期间不良反应发生率。结果观察组患者治疗有效率为64.4%,明显高于对照组患者的42.2%,差异有统计学意义(P<0.05);观察组患者化疗期间胃肠道反应、骨髓抑制、神经毒性、静脉炎及手足综合征等不良反应发生率与对照组相比,均较低,差异均有统计学意义(均P<0.05)。结论奥沙利铂联合卡培他滨治疗结肠癌期间,护理干预不仅能够提高治疗的临床效果,还能降低化疗期间不良反应,提高患者生活质量。
Objective To investigate the effect of nursing intervention on adverse reactions of oxaliplatin and capecitabine in patients with colon cancer. Methods Ninety patients with colon cancer who were admitted to Zhongshan Hospital Affiliated to Dalian University from January 2015 to January 2016 were randomly divided into observation group (nursing intervention) and control group (conventional nursing), with 45 cases in each group , Both groups were given oxaliplatin combined with capecitabine chemotherapy. The clinical efficacy after treatment and the incidence of adverse reactions during chemotherapy were compared between the two groups. Results The effective rate of treatment in observation group was 64.4%, which was significantly higher than that in control group (42.2%) (P <0.05). The gastrointestinal reactions, myelosuppression, neurotoxicity, phlebitis And hand-foot syndrome and other adverse reactions compared with the control group were lower, the differences were statistically significant (P <0.05). Conclusion During the treatment of colon cancer with oxaliplatin combined with capecitabine, nursing intervention can not only improve the clinical effect of treatment, but also reduce the adverse reactions during chemotherapy and improve the quality of life of patients.