论文部分内容阅读
[目的]对消化系统不同器官之胃癌、肝癌、结肠癌患者进行白细胞介素1(IL-1)、肿瘤坏死因子α(TNF-α)检测,比较3组间及治疗前、后是否存在差异。[方法]采用放射免疫分析法,对胃癌11例、肝癌15例、结肠癌12例患者化疗前、后进行IL-1、TNF-α检测。[结果]胃癌、肝癌患者的IL-1、TNF-α检测值比正常值增加4倍,而结肠癌仅增加2倍,与前2组比较差异有统计学意义(P<0.05)。化疗后与化疗前比较,胃癌、肝癌患者的IL-1、TNF-α值均显著下降(P<0.05),结肠癌患者亦有下降但无统计学意义;3组间比较差异无统计学意义(P>0.05)。[结论]IL-1、TNF-α主要与组织器官的炎症程度相关,炎症的启动因子不同则宿主产生的细胞因子和炎症因子参与炎症反应存在较大差异,而近端结肠癌与患者的背景基因和遗传因素相关。
[Objective] To detect the levels of interleukin 1 (IL-1) and tumor necrosis factor α (TNF-α) in gastric cancer, liver cancer and colon cancer in different organs of the digestive system and to compare the differences between the three groups before and after treatment . [Methods] Radioimmunoassay was used to detect IL-1 and TNF-α before and after chemotherapy in 11 cases of gastric cancer, 15 cases of liver cancer and 12 cases of colon cancer. [Results] The levels of IL-1 and TNF-α in gastric cancer and hepatocellular carcinoma were increased fourfold compared with the normal values, while the colon cancer only increased twofold, which was significantly different from the former two groups (P <0.05). Compared with those before chemotherapy, the levels of IL-1 and TNF-α in gastric cancer and hepatocellular carcinoma were significantly decreased (P <0.05) and decreased in colon cancer patients, but there was no significant difference between the three groups (P> 0.05). [Conclusion] The levels of IL-1 and TNF-α are mainly related to the degree of inflammation in tissues and organs. The different initiators of inflammation are different in the host inflammatory cytokines and inflammatory factors, while the background of proximal colon cancer and patients Genetic and genetic factors.