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[目的]观察紫杉醇联合奥沙利铂治疗胃癌的疗效。[方法]将胃癌患者分为3组,分别采取奥沙利铂联合5-氟尿嘧啶(5-FU)、紫杉醇联合5-Fu及紫杉醇联合奥沙利铂治疗,观察治疗效果和不良反应。[结果]奥沙利铂联合5-Fu、紫杉醇联合5-Fu及紫杉醇联合奥沙利铂组治疗的总有效率分别为35.29%、36.84%和52.38%,后组与前2组比较P<0.05;不良反应主要是血液学毒性、恶心呕吐、末梢神经感觉异常及脱发。[结论]紫杉醇联合奥沙利铂治疗胃癌疗效明显,不良反应在耐受范围之内,安全性好,值得临床推广应用。
[Objective] To observe the efficacy of paclitaxel combined with oxaliplatin in the treatment of gastric cancer. [Methods] The patients with gastric cancer were divided into 3 groups and were treated with oxaliplatin combined with 5-fluorouracil (5-FU), paclitaxel combined with 5-Fu and paclitaxel combined with oxaliplatin to observe the therapeutic effect and adverse reactions. [Results] The total effective rates of oxaliplatin combined with 5-Fu, paclitaxel combined with 5-Fu and paclitaxel plus oxaliplatin were 35.29%, 36.84% and 52.38%, respectively, P < 0.05; adverse reactions are mainly hematological toxicity, nausea and vomiting, peripheral nerve sensory abnormalities and hair loss. [Conclusion] The combination of paclitaxel and oxaliplatin has obvious curative effect on gastric cancer. The adverse reactions are within the tolerance range and safety is good, which is worthy of clinical application.