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目的探讨人绒毛膜促性腺激素(Human chorionic gonadotropin,HCG)对解冻胚胎移植(FET)临床妊娠结局的影响。方法回顾性分析海南医学院附属医院生殖医学中心2011年1月至2014年4月4 503例解冻胚胎移植周期不孕症患者,根据胚胎移植后黄体期支持是否注射HCG分为HCG组和对照组,HCG组在移植胚胎后联合使用黄体酮和HCG,对照组在移植后单用黄体酮,对比分析两组患者临床妊娠结局。结果 HCG组和对照组的临床妊娠率分别为32.35%及34.86%,差异无统计学意义(P>0.05);HCG组的继续妊娠率低于对照组(57.32%和71.14%),差异无统计学意义(P>0.05)。结论解冻胚胎周期黄体支持治疗添加HCG对临床继续妊娠率没有显著的影响;患者年龄、临床治疗方案、不孕年限、ET次数、复苏率是影响继续妊娠的主要因素。
Objective To investigate the effect of human chorionic gonadotropin (HCG) on clinical pregnancy outcome of thawed embryo transfer (FET). Methods Retrospective analysis of 4 503 cases of thawed embryo transfer infertility patients from January 2011 to April 2014 in Reproductive Medicine Center of Affiliated Hospital of Hainan Medical College were divided into HCG group and control group according to whether HCG was injected during luteal phase after embryo transfer In the HCG group, progesterone and HCG were combined after embryo transfer, while in the control group, progesterone alone was used in the control group. The clinical pregnancy outcomes were compared between the two groups. Results The clinical pregnancy rates in HCG group and control group were 32.35% and 34.86% respectively, with no significant difference (P> 0.05). The pregnancy rates in HCG group were lower than those in control group (57.32% and 71.14%) Significance (P> 0.05). Conclusion Thawed embryo cycle luteal support treatment with HCG has no significant effect on the clinical follow-up pregnancy rate; patient age, clinical treatment regimen, duration of infertility, number of ET, recovery rate are the main factors that affect the continuation of pregnancy.