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最近10年来,扩大了抗菌谱的一些抗生素被批准用于临床。曾经预料这些新药会像以前用的青霉素类和头孢菌素类同样的安全;然而,已有戒酒硫(Disulfiram)反应,损害止血功能、出血,以及惊厥发作等报道,令人对这些β-内酰胺中某些新药的真实安全性,产生了关注。论及β-内酰胺类引起的出血频率,特别混乱,对这些药物引起止血功能缺陷的不同机制,也有误解,这偶或导致对β-内酰胺治疗的病人中发生的出血,给以不当的处理,所以我们认为,需要回顾这些问题,并对β-内酰胺类治疗期间可能增加外科病人出血危险的那些致病机制应予以
In the last 10 years, some antibiotics that have expanded their antimicrobial spectrum have been approved for clinical use. It has been anticipated that these new drugs will be as safe as previously used penicillins and cephalosporins; however, there have been reports of disulfiram reactions that impair hemostatic function, bleeding, and seizures, The real safety of some of the new drugs in lactams has drawn attention. The frequency of bleeding caused by beta-lactams is particularly chaotic and there are misunderstandings about the different mechanisms by which these drugs cause defects in hemostasis, which occasionally leads to bleeding in patients treated with [beta] -lactam, Therefore, we believe that those mechanisms that need to be reviewed and those that may increase the risk of bleeding from surgical patients during β-lactam treatment should be