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目的：通过测定连续口服甲磺酸培氟沙星后的健康志愿者体内的稳态血药浓度，提出该药用于抗感染治疗的给药方案。方法：选择男性健康志愿者，ＨＰＬＣ测定血药浓度，用３Ｐ８７和Ｓｃｈｉｍ程序处理数据。结果：连续６ｄ给药（４００ｍｇｂｉｄ）后可达稳态血药浓度，其中Ｃ_（ｓｓｍａｘ）＝１２．２４±３．８７ｍｇ／Ｌ，Ｃ_（ｓｓｍｉｎ）＝７．４７±２．３６ｍｇ／Ｌ，积蓄比Ｒ＝２．３６。结论：该药的积蓄情况比较严重，但４００ｍｇｂｉｄ给药方式是安全的。同时建议４００ｍｇｂｉｄ用于重度感染，２００ｍｇｂｉｄ用于中轻度感染，８００ｍｇｂｉｄ的方案不予考虑。
OBJECTIVE: To determine the steady-state plasma concentration in healthy volunteers after continuous oral administration of pefloxacin mesylate, and to propose a regimen of this drug for anti-infective therapy. Methods: Male healthy volunteers were selected, plasma concentration was determined by HPLC, and data were processed by 3P87 and Schim program. Results: Steady-state plasma concentration reached the peak after continuous 6d administration (400mgbid), with Cmax (ssmax) = 12.24 ± 3.87mg / L and C ssmin = 7.47 ± 2.36mg / L Ratio R = 2.36. Conclusion: The drug is more serious savings, but 400mgbid administration is safe. Also recommended 400mgbid for severe infections, 200mgbid mild infections, 800mgbid program will not be considered.