Insights into gastric neuroendocrine tumors burden

• 作 者: Taíssa Maíra Thomaz Araújo Williams Fernandes Barra André Salim Khayat Paulo Pimentel de
• 机 构: Assump??o Oncology Research Center,Federal University of Pará,
• 出 处: Chinese Journal of Cancer Research
• 发表日期: 2017年02期
• 关键词: neuroendocrine aggressive potentially challenging restricted neoplasms apparentl

Type 1 gastric neuroendocrine tumors(g NETs)are usually small lesions,restricted to mucosal and sub-mucosal layers of corpus and fundus,with low aggressive behavior,for the majority of cases.Nevertheless,some cases present aggressive behavior.The increasing incidence of g NETs brings together a new relevant problem:how to identify potentially aggressive type 1 g NETs.The challenging problem seems to be finding out signs or features able to predict potentially aggressive cases,allowing a tailored approach,since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors.Additionally,it is also important to try to find out explanations for increasing incidence,as well as to identify potential targets aiming to reach better control of this neoplasia.Here,we discuss potential pathways implicated in aggressive behavior,as well as new strategies to improve clinical management of these tumors.

Type 1 gastric neuroendocrine tumors (g NETs) are usually small lesions, restricted to mucosal and sub-mucosal layers of corpus and fundus, with low aggressive behavior, for the majority of cases. Nevertheless, some cases present aggressive behavior. The increasing incidence of g NETs brings together a new relevant problem: how to identify potentially aggressive type 1 g NETs.The difficult problem seems to be finding out signs or features able to predict potentially aggressive cases, allowing a tailored approach, since the involved societies dedicated to provide guidelines for management of these neoplasms apparently failed in producing staging systems able to accurately predict prognosis of these tumors. Additionally, it is also important to try to find explanations for improving incidence, as well as to identify potential targets aiming to reach better control of this neoplasia.Here, we discuss potential pathways implicated in aggressive behavior, as well as new strategies to improve clinical management of these tumors.