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2型糠尿病77例,分为肥胖与非肥胖组,测定空腹胰岛素,血流变学等检查。结果肥胖组胰岛素敏感性指数低于非肥胖组,空腹血胰岛素、血尿酸高于非肥胖组,肥胖的糖尿病患者,其血脂及血液流变学变化,TG及TC,均与非肥胖者比较有显著差异,但2组的APOA、APOB、LP(a)、LDL无显著差异。其全血粘度高切、低切,血浆粘度均高于肥胖者,而红细胞压积高于非肥胖者,差异显著。结论肥胖的2型糖尿病患者存在明显的胰岛素敏感性减低、高胰岛素血症、高尿酸血症、高粘血症及脂代谢紊乱,提示改善肥胖本身,降低血粘度以及针对脂毒性的治疗在2型糖尿病综合治疗中的重要地位。
Type 2 diabetes mellitus in 77 cases, divided into obesity and non-obese group, determination of fasting insulin, hemorheology and other tests. Results The insulin sensitivity index of obesity group was lower than that of non-obese group, fasting blood insulin, higher serum uric acid than non-obese group, obese diabetic patients, the changes of blood lipid and hemorheology, TG and TC, Significant differences, but two groups of APOA, APOB, LP (a), LDL no significant difference. The whole blood viscosity of high-cut, low-cut, plasma viscosity were higher than those who were obese, and hematocrit than non-obese, significant difference. Conclusions Obese patients with type 2 diabetes have significantly reduced insulin sensitivity, hyperinsulinemia, hyperuricemia, hyperviscosity and dyslipidemia, suggesting that the improvement of obesity itself, reducing blood viscosity and the treatment of lipid toxicity in 2 Type diabetes comprehensive treatment of the important position.