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目的探讨人非小细胞肺癌中ｐ１６基因表达产物的表达及其临床意义。方法应用免疫组织化学ＬＳＡＢ法检测７０例人非小细胞肺癌组织ｐ１６基因产物的表达水平，并以２０例正常肺组织标本作对照。结果肺癌组织ｐ１６基因产物阳性表达率为６１．３８％，癌旁肺组织为８９．１４％，正常肺组织为８８．２４％。肺癌中ｐ１６表达水平降低的程度与肺癌细胞分化、原发肿瘤大小和肺癌转移有密切关系（Ｐ＜０．０１或Ｐ＜０．０５），而与肺癌病期、组织学类型、肿瘤部位和患者年龄无明显关系（Ｐ＞０．０５）。结论研究结果表明ｐ１６基因可能参与调控肺癌的发生、发展和转移过程。
Objective To investigate the expression and clinical significance of p16 gene expression product in human non-small cell lung cancer. Methods The expression of p16 gene product in 70 cases of human non-small cell lung cancer was detected by immunohistochemistry LSAB method, and 20 normal lung tissues were used as controls. Results The positive expression rate of p16 gene product was 61.38% in lung cancer tissues, 89.14% in adjacent lung tissues, and 88.24% in normal lung tissues. The decrease of p16 expression in lung cancer was closely related to the differentiation of lung cancer cells, the size of primary tumor and the metastasis of lung cancer (P<0.01 or P<0.05), but it was related to the stage, histological type, tumor site and lung cancer. The patient’s age was not significantly related (P>0.05). Conclusions The results suggest that the p16 gene may be involved in the regulation of the occurrence, progression and metastasis of lung cancer.