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本文对239例IgA肾病进行了形态学和临床参数的研究,分析了肾小管间质损害与肾小球损害两者的关系及其对预后的重要性。肾活检时平均年龄33.0±11.8岁,30岁以上肾小球肾炎的进展较年轻者快。总肾存活率5年为91.8%,10年为80.5%。30岁以上肾存活率(KSR)5年为88.7%,10年为72.6%。在176例男性中KSR5年及10年分别为91.1%和83.7%,33例女性KSR5年及10年分别为93.8%和69.1%,无显著差异。在组织学研究中,中度到严重的系膜增生改变的IgA肾病较轻微或微小毛细血管内损害的IgA肾病预后差。以往对系膜增生性肾类(mesGN)的研究中,中度及重度的mesGN较之轻微或微小增生性毛细血管内肾炎(MPIGN)常合并肾小管间质性损害。无肾小管间质改变
In this paper, 239 cases of IgA nephropathy were studied morphological and clinical parameters, the relationship between tubulointerstitial damage and glomerular damage and its prognostic importance. Kidney biopsy average age of 33.0 ± 11.8 years, 30 years of age glomerulonephritis progress faster than younger. The total kidney survival rate was 91.8% in 5 years and 80.5% in 10 years. Survival rates (KSR) over 30 years old were 88.7% for 5 years and 72.6% for 10 years. Among 176 men, KSR had 91.1% and 83.7% of the 5 years and 10 years, respectively, while 33 women had 93.8% and 69.1% of the 5 years and 10 years of KSR, respectively, with no significant difference. In histological studies, IgA nephropathy with moderate to severe altered mesangial proliferation has a poor prognosis of IgA nephropathy with minor or minimal capillary damage. In previous studies of mesGN, moderate and severe mesGN was associated with tubulointerstitial lesions compared with mild or minimal proliferative endopelvic nephritis (MPIGN). No tubulointerstitial changes