论文部分内容阅读
人类疟疾由四种疟原虫引起。其中的三种即三日疟原虫,卵形疟原虫和间日疟原虫,由于生活史中红细胞外期以及复发能力的不同,可有中等到长期的感染期,近来发现肝实质细胞内有“休眠体”,为复发提供了依据。以上三种疟原虫只侵犯一定成熟程度的红细胞,因此,感染受到一定的局限。恶性疟原虫有惊人的繁殖力,能侵犯早期到完全成熟的红细胞,原虫血症也最严重,但无以红细胞外期保存的形式。早期,疟疾综合症是以一系列反复发作的寒战和发热为特点,可能由于宿主对成熟裂殖体引起的红细胞破裂以及突然释放出来的原虫产物的反应所致。脾、肝、心、肾、血、脑的受累可有局部的特殊临床征候,并导致病情恶化,甚至死亡。与疟疾感染相联系的免疫力的普遍现象主要是抗裂殖子特异性抗体反应的最后产
Human malaria is caused by four types of Plasmodium. Three of them, Plasmodium malariae, Plasmodium ovale and Plasmodium vivax, may have moderate to long-term infection due to the different stages of erythrocyte and relapse in their life history. Recently, it has been found that there are “ Dormant body ”, provided the basis for relapse. The above three types of malaria parasites only infringe a certain degree of maturity of red blood cells, therefore, the infection is subject to certain limitations. Plasmodium falciparum has surprising fecundity and can invade early to fully mature erythrocytes, and parasitemia is also the most serious, but not in the form of erythrocytic preservation. Early on, the malaria syndrome was characterized by a series of recurrent chills and fever, possibly due to the host’s reaction to the rupture of red blood cells caused by mature schizonts and the sudden release of protozoal products. Spleen, liver, heart, kidney, blood, brain involvement may have special local clinical symptoms, and lead to the deterioration of the disease, and even death. The prevalence of immunity associated with malaria infection is largely the culmination of the anti-merozoite-specific antibody response