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众所周知,雌、孕激素单独或联合给药影响血清脂质含量。口服避孕药(OCs)影响的大小取决于含雌、孕激素的性质和剂量。从大量流行病学研究表明,发生心血管疾病的危险性与血脂有关,特别注意到与高密度脂蛋白胆固醇(HDL-C)含量与发生心血管疾病呈负相关。大多数脂蛋白成份处于不稳定状态,由于胆固醇仅占HDL分子的15%(10～20%),HDL-C的测定可引起误解,因此,测定此分子的蛋白部份脱辅基蛋白(apoprotein)可提供更多的信息。
As we all know, estrogen and progesterone alone or in combination affect the serum lipid content. The effect of oral contraceptives (OCs) depends on the nature and dosage of estrogen-containing progesterone. From a large number of epidemiological studies have shown that the risk of cardiovascular disease and blood lipids, with particular attention to the content of high-density lipoprotein cholesterol (HDL-C) and the occurrence of cardiovascular disease was inversely correlated. Most of the lipoprotein components are in an unstable state. Since cholesterol accounts for only 15% (10-20%) of HDL molecules, determination of HDL-C can cause misunderstandings. Therefore, determination of the protein apoprotein ) Can provide more information.