Relationships among KRAS mutation status,expression of RAS pathway signaling molecules,and clinicopa

• 作 者: Xiang-Bin Wan Ai-Qin Wang Jian
• 机 构: DepartmentofGeneralSurgery,DepartmentofPharmacy,DepartmentofMedicalOncology,China-US（Henan）HormelCan
• 出 处: 世界胃肠病学杂志:英文版
• 发表日期: 2019年7期
• 关键词: Colorectal cancer KRAS gene KRAS PROTEIN BRAF PROTEIN MEK PROTEIN ERK PROTEIN
• 基金项目: the Henan Department of Science and Technology,China,No.162102310317.

BACKGROUND The RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways all belong to mitogen-activated protein kinase(MAPK)signaling pathways,Mutations in any one of the upstream genes(such as the RAS gene or the BRAF gene)may be transmitted to the protein t