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目的：研究BNP在评估慢性阻塞性肺疾病急性加重期患者舒张功能障碍中的应用价值。方法回顾性分析我院2013年10月至2014年10月76例AECOPD患者，统计其血气、肺功能、BNP、心脏彩超。结果76例住院AECOPD患者BNP(126.2±110.5)ng/ml，对其中15例随访患者分析表明，其稳定期BNP(22.3±7.8)ng/ml，急性加重期为(86.8±30.3)ng/ml，出院时为(18.7±7.0)ng/ml，急性加重期与稳定期、出院时比较，有显著统计学差异(P=0.00)；相关性分析表明，AECOPD患者BNP水平与LVDd、LVDs、EDV、ESV、E/Ea相关（P＜0.05），与LVEF无相关性（P=0.32）。结论AECOPD患者血浆BNP水平显著升高，与舒张功能障碍相关，BNP可作AECOPD左心舒张功能障碍的评估指标。“,”purpose To examine the association of diastolic and systolic dysfunction and plasma BNP levels in Acute exacerbation of chronic obstructive pulmonary disease (AECOPD);Methods The clinic data of 76 subjects of AECOPD in our hospital,admitted from October 2013 to October 2014, to analyze its blood gas analysis,pulmonary function,B type natriuretic peptide and ultrasonic cardiogram;Results 76 hospitalized subjects, Mean standard deviation of BNP was (126.2±110.5)ng/ml.Analyzed 15 cases fol ow-up AECOPD ,the BNP levels of stable COPD was (22.3±7.8)ng/ml,acute exacerbation was (86.8±30.3)ng/ml,and after AECOPD was(18.7±7.0)ng/ml,ONE-WAY ANOVA proved its statistical differences between acute exacerbation and stable COPD, after AECOPD (F=64.11,P=0.00).Pearson correlation demonstrated that BNP was correlated with LVDd, LVDs, EDV, ESV, and E/Ea (P<0.05,respectively),However,there was no correlation with LVEF(P=0.32). Conclusion It appears that AECOPD may have a high plasma level of BNP that is attributable to heart systolic dysfunction.