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目的为有效治疗行胃癌根治术后出现腹腔淋巴结转移癌,临床探究放疗同时行替吉奥序贯化疗的效果以及用药安全性情况。方法 96例入院行胃癌根治术后发现腹腔淋巴结转移癌的患者,按双盲法随机分为单一组和联合组,各48例。单一组患者采用放疗治疗,联合组在此基础上加用替吉奥序贯化疗治疗。观察两组患者瘤体控制效果以及治疗期间不良反应情况。结果联合组临床有效率(RR)为58.3%,明显优于单一组的27.1%(P<0.05);两组患者肝功能损害、白细胞减少发生率比较,差异无统计学意义(P>0.05);单一组消化道反应、肾功能损害以及血小板减少发生率依次为14.6%、14.6%、12.5%均高于联合组的4.2%、2.1%、2.1%(P<0.05)。结论临床对出现腹腔淋巴结转移癌的胃癌患者,采用放疗同时行替吉奥序贯化疗,患者疾病得到有效控制,且不良反应少。
Objective To effectively treat gastric cancer with celiac lymph node metastasis after radical operation, to study the effect of radiotherapy combined with sequential chemotherapy and medication safety. Methods A total of 96 patients admitted to our hospital with gastric cancer with celiac lymph node metastasis were randomly divided into single group and combined group according to double-blind method, 48 cases in each group. A single group of patients treated with radiotherapy, the combined group on the basis of this for the treatment of sequential chemotherapy. Observe the effect of tumor control and the adverse reactions during the treatment in both groups. Results The clinical effective rate (RR) of the combination group was 58.3%, which was significantly better than that of the single group (27.1%, P <0.05). There was no significant difference between the two groups in the incidence of hepatic dysfunction and leukopenia (P> 0.05) The rates of digestive tract reaction, renal dysfunction and thrombocytopenia in single group were 14.6%, 14.6% and 12.5%, respectively, which were higher than those in the combined group (4.2%, 2.1%, 2.1%, P <0.05). Conclusions In patients with gastric cancer with celiac lymph node metastasis, sequential radiotherapy and sequential chemotherapy were used. Patients’ disease was effectively controlled with few adverse reactions.