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目的 :探讨铅和乙醇联合作用对雄性大鼠生殖内分泌的影响。方法 :雄性大白鼠 54只 ,体重(2 0 7± 17) g ,采用 2× 3析因设计方法随机分为 9组 ,每组 6只 ,1次 /d灌胃 ,5次 /周 ,连续 4周 ,染毒期满断头处死 ,取血做T、FSH、LH及血铅的分析。结果 :染毒组与对照组比较 ,T值降低 ,FSH、LH、血铅增高 (P <0 .0 1) ,联合染毒组与各单独染毒组 (除B组T值 )比较差异有显著性 (P <0 .0 1、P <0 .0 5) ;铅、乙醇及二者联合分别对 3项内分泌指标及血铅的影响有显著性意义 (P <0 .0 1、P <0 .0 5) ;逐步回归显示血铅与FSH、LH呈正相关关系 ,与T呈负相关。结论 :铅和乙醇联合作用对雄性大鼠生殖内分泌激素T、FSH和LH水平变化有明显的增毒作用。
Objective: To investigate the effects of lead and ethanol on reproductive endocrine in male rats. METHODS: Fifty-four male rats weighing 2707 g were randomly divided into 9 groups with 2 × 3 factorial design. Each group consisted of 6 rats in each group, once a day for 5 times a week for continuous 4 weeks, the decapitation at the end of the period of poisoning, blood T, FSH, LH and blood lead analysis. Results: Compared with the control group, T value decreased, FSH, LH and blood lead increased (P <0.01). There was significant difference between the combined treatment group and each treatment group (P <0.01, P <0.05). The combination of lead and ethanol and their combination on three endocrine indexes and blood lead were significant (P <0.01, P < 0 .0 5). The stepwise regression showed that there was a positive correlation between blood lead and FSH and LH and a negative correlation with T. Conclusion: The combined effect of lead and ethanol has obvious toxic effects on the changes of reproductive and endocrine hormones T, FSH and LH in male rats.