镉对溶菌酶肾脏清除率的影响

• 作 者: 王翔朴 谢红 王军 周晓娟
• 机 构: 湖南医科大学环境医学研究室
• 出 处: 劳动医学
• 发表日期: 1996年03期
• 关键词: 清除率 中毒性肾损害 肾小管上皮细胞 大鼠 降解功能 肾小管细胞 肾小球滤过率 消除率 王翔朴 生理盐水溶液

利用大鼠镉中毒性肾损害模型，观察了镉对溶菌酶肾脏清除率的影响。结果镉染毒组血、尿溶菌酶均升高，肾小管对溶菌酶的重吸收率显著低于对照组，而溶菌酶的肾脏消除率两组差异则无显著性。认为镉染毒组动物肾小管上皮细胞受损害后，抑制了肾小管上皮细胞对溶菌酶的重吸收和降解功能，从而造成血及尿中溶菌酶浓度升高，而对不经降解的溶菌酶分子运转过程的影响较小

The model of cadmium toxicity in rats was used to observe the effects of cadmium on the renal clearance rate of lysozyme. Results The levels of blood and urine lysozyme in cadmium-exposed group were all increased, and the reabsorption of lysozyme in renal tubules was significantly lower than that in control group. However, there was no significant difference between the two groups in lysozyme renal elimination rate. It is considered that the renal tubular epithelial cells in cadmium-exposed group are damaged, which inhibits the reabsorption and degradation of lysozyme in renal tubular epithelial cells, resulting in the increase of the concentration of lysozyme in blood and urine, but not the degradation of lysozyme The molecular operation has little effect