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本研究为确定用大剂量电离辐射是否可以对狒狒产生一种有效的疫苗,这种疫苗经NIH/Nmri CV品系小鼠实验已证明是有效的。作者用10只体重6～8公斤的幼年狒狒,兔疫组9只(5只雄,4只雌),对照组10只(5只雄,5只雌)。48只6周龄雌性NIH/NmriCV品系小鼠,波多黎各品系曼氏血吸虫尾蚴从光滑双脐螺(Biomphalaria glabrata)逸出后照射致弱,用于免疫。攻击感染用未经照射的尾蚴。免疫和攻击感染狒狒均经肤给予尾蚴。狒狒和小鼠无论免疫或攻击感染所用的尾蚴都是同一批的。
This study was conducted to determine whether babies can be effectively vaccinated with high-dose ionizing radiation. This vaccine has been shown to be effective in NIH / Nmri CV mouse strains. The authors used 10 young baboons weighing 6 to 8 kg, 9 rabbits (5 males and 4 females) and 10 rabbits (5 males and 5 females) in the control group. Forty eight 6-week-old female NIH / NmriCV strains of mice, Puerto Rico, were challenged by immunization with cercaria larvae of Cercospora mansoni after escaping from a smooth snakehead (Biomphalaria glabrata). Infected with non-irradiated cercariae. Immunization and challenge baboons are given cercariae via the skin. Babies and mice have the same lot of cercariae that immunize or challenge infections.