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目的：探讨利培酮联合认知干预对精神分裂症患者预后及代谢指标的影响。方法将66例精神分裂症患者按随机数字表法分为两组，两组均口服利培酮治疗，观察组在此基础上联合认知干预治疗。观察6个月。治疗前后采用简明精神病量表评定精神症状改善状况，自知力与治疗态度问卷评定患者对疾病的认识及服药态度，社会功能缺陷筛选量表评价患者的社会角色功能及功能缺陷程度。同时检测空腹血糖、三酰甘油、总胆固醇代谢指标的变化。结果治疗后观察组各量表评分均较治疗前有显著改善，且显著优于对照组（P＜0．01）；治疗前后观察组各项代谢指标水平均无显著变化（P＞0．05），对照组治疗后各项代谢指标水平均较治疗前显著升高（P＜0．01），且显著高于研究组（P＜0．01）。结论利培酮联合认知干预治疗精神分裂症患者具有协同增效作用，能提高患者对疾病的认识能力及社会功能，有效控制各项代谢指标水平的变化，显著优于单用利培酮治疗。“,”Objective To explore the effects of risperidone plus cognitive intervention on prognosis and metabolic parameters of schizophrenic .Methods Sixty‐six schizophrenics were assigned to two groups ac‐cording to random number table ,both groups took orally risperidone ,on this basis observation group was plus cognitive intervention for 6 months .The improvement states of mental symptoms were assessed with the Brief Psychiatric Rating Scale (BPRS) before and after treatment ,realization to the disease and atti‐tude to treatment with the Insight and Treatment Attitude Questionnaire (ITAQ) ,and social role function and disability degrees with the Social Disability Screening Schedule (SDSS ) .Changes of fasting plasma glucose FPG) ,triglyceride (TG) and total cholesterol (TC) metabolic indexes were detected at the same time .Results After treatment all scales scores improved more significantly compared with pre‐treatment in observation group and than in control group (P0 .05) ,those heightened more significantly in control group (P<0 .01) and were significantly higher than in observation group (P<0 .01) .Conclusion Risperidone plus cognitive intervention have a synergism in the treatment schizophrenia ,could boost patients’ realization to the disease and social function ,effectively control the changes of all metabolic indexes ,and are significant‐ly better than single risperidone treatment .