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目的探讨乙胺丁醇中毒性视神经病变的防治。方法分析21例不同剂量与视功能损害的关系及治疗迟和早的效果。结果日剂量组视力损害:发生时间0.75g组6.1月为最迟,1.5g组2.3月为最早,各组比较P<0.005;下降程度0.75g组0.73为最小,1.5g组0.032为最大,P<0.0025。视野、色觉:0.75g组仍正常,余随日剂量增大损害加重。视功能损害与总剂量关系不大。疗效:10天内开始治疗平均视力达1.15,>20天者0.33,各组比较P<0.02;视野、色觉10天内治疗全部恢复正常,>20天者仅1例恢复正常。结论乙胺丁醇视功能损害与日剂量成正比,小剂量可减少损害.定期检查、监测视功能,一旦发生损害,立即停药治疗挽救视功能。
Objective To investigate the prevention and treatment of ethambutol poisoning optic neuropathy. Methods 21 cases of different doses and visual impairment and treatment of early and late treatment effect. Results Day dose group, visual impairment: 0.75g group occurred at the latest in 6.1, 1.5g group 2.3 months earliest, each group compared P <0.005; decreased 0.75g group 0.73 minimum, 1.5g group 0.032 maximum, P <0.0025. Visual field, color vision: 0.75g group is still normal, I increased with increasing daily dose of damage worse. The impairment of visual function has little to do with the total dose. Efficacy: The average visual acuity of 1.15 in 10 days, 0.33 in> 20 days and P <0.02 in each group. The treatment of visual field and color vision returned to normal within 10 days, and only 1 case returned to normal in> 20 days. Conclusion Ethambutol visual impairment is proportional to the daily dose, low dose can reduce damage.Regular examination, monitoring visual function, in the event of damage, immediately stop treatment of visual function.