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目的:观察替米沙坦联合胺碘酮治疗阵发性心房颤动(房颤)的长期疗效。方法:将阵发性房颤112例随机分为胺碘酮组(对照组)和胺碘酮+替米沙坦组(观察组)各56例,治疗随访18个月,比较两组治疗后窦性心律维持率和治疗前后6、12、18个月左心房内径。结果:治疗18个月后,对照组左心房内径显著大于观察组(P<0.05)。观察终点时,对照组窦性心律维持率为58.2%,观察组为82.7%,两组比较,差异显著(P<0.05)。结论:胺碘酮联合替米沙坦在维持窦性心律方面优于胺碘酮,且能抑制左心房扩大。
Objective: To observe the long-term efficacy of telmisartan combined with amiodarone in the treatment of paroxysmal atrial fibrillation (atrial fibrillation). Methods: One hundred and twelve cases of paroxysmal atrial fibrillation were randomly divided into amiodarone group (control group) and amiodarone + telmisartan group (observation group), 56 cases were followed up for 18 months. After the treatment, Sinus rhythm maintenance rate and 6,12,18 months before and after treatment of left atrial diameter. Results: After 18 months of treatment, the left atrial diameter of the control group was significantly larger than that of the observation group (P <0.05). At the end of observation, the maintenance rate of sinus rhythm in control group was 58.2% and that of observation group was 82.7%. There was significant difference between the two groups (P <0.05). Conclusion: Amiodarone combined with telmisartan is superior to amiodarone in maintaining sinus rhythm and can inhibit left atrial enlargement.