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本文分析匹兹堡长老会大学医院,自1954年1月至1978年8月间,152例急非淋白血病(ANLL)的尸检资料,其中9例(5.9%)发生 ANLL 前曾因其他疾病进行化疗,该9例均在1974～1978年间,占此5年中尸检44例 ANLL 的22.7%,而1974年前未见1例.文中并综合了这9例及另外11例未作尸检病例的临床和血液学资料,其原发病包括非何杰金氏淋巴瘤5例,何杰金病6例,多发性骨髓瘤3例、慢淋2例、癌4例及类风湿性关节炎使用免疫抑制剂治疗者1例。其中8例曾接受放疗。15例在发生 ANLL 前有血细胞减少,其中10例全血细胞减少、2例贫血、2例贫血加血小板减少,1例仅
This article analyzes autopsy data from 152 patients with acute non-leukemia (ANLL) from January 1954 to August 1978 at the Presbyterian Hospital in Pittsburgh. Of these, 9 (5.9%) had prior chemotherapy for other diseases with ANLL, All of the 9 cases were from 1974 to 1978, accounting for 22.7% of 44 ANLL cases in autopsy in this 5 years, but none in 1974. The clinical data of 9 cases and 11 cases without autopsy Hematology data, the primary disease, including non-Hodgkin’s lymphoma in 5 cases, Hodgkin’s disease in 6 cases, 3 cases of multiple myeloma, 2 cases of chronic lymphocytic leukemia, 4 cases of cancer and rheumatoid arthritis using immunosuppression Treatment of patients in 1 case. Eight of them had received radiotherapy. Fifteen patients had cytopenias before ANLL, including 10 cases of pancytopenia, 2 cases of anemia, 2 cases of anemia plus thrombocytopenia and 1 case of only