论文部分内容阅读
[目的]评价CBCT图像引导技术下SBRT治疗原发性肺癌或肺转移瘤的安全性和初步疗效。[方法]2012年8月至2013年10月共9例患者在浙江省肿瘤医院接受CBCT图像引导下SBRT胸部放疗,中位年龄68岁。每次照射前行KV级CBCT扫描并在线配准。每次照射剂量5.0~12.5Gy,每日1次,中位照射次数8次(4~10次);BED 76.8~112.5Gy(中位96Gy)。[结果]9例患者均安全完成放疗,总有效率为77.8%。其中CR 1例(11.1%),PR 6例(66.7%),SD 2例(22.2%),无PD患者,未出现3度以上放射性毒副反应。中位随访8.8个月(1.3~14.6个月),1年局部控制率及总生存率分别为88.9%和100%。[结论]CBCT图像引导下SBRT治疗早期肺癌或肺转移瘤近期疗效明确,毒副反应低,远期疗效有待进一步随访。
[Objective] To evaluate the safety and primary efficacy of SBRT in primary lung cancer or lung metastases under CBCT image guidance. [Methods] From August 2012 to October 2013, a total of 9 patients received SBRT chest radiotherapy under the guidance of CBCT images at Zhejiang Cancer Hospital. The median age was 68 years. KV class CBCT scan and online registration before each irradiation. Each exposure dose 5.0 ~ 12.5Gy, once a day, the median number of exposure 8 times (4 to 10 times); BED 76.8 ~ 112.5Gy (median 96Gy). [Results] The radiotherapy was safely completed in all 9 patients, with a total effective rate of 77.8%. There were 1 case of CR (11.1%), 6 cases of PR (66.7%) and 2 cases of SD (22.2%) without radiotherapy. The median follow-up period was 8.8 months (1.3-14.6 months). The 1-year local control rate and overall survival rate were 88.9% and 100% respectively. [Conclusion] CBCT image-guided SBRT treatment of early lung cancer or lung metastases with a clear short-term effect, low toxicity, long-term efficacy needs further follow-up.