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在亚急性和慢性毒性试验中,常以某些重要器官的绝对或相对重量(也称器官重与体重比或脏器系数)表示受试药物对动物的影响,但是当试验结束时,如试验组动物的体重显著低于对照组,则表示存在着一定的问题。首先必须区别器官重量的改变是直接由于受试药物所致,抑或由于进食量减少所造成,为此作者作了一个模拟试验,观察喂养不足对器官重量的影响。体重110g的雄性大鼠,分为五组:Ⅰ组自由进食13周,最终体重为366g左右,Ⅱ组自开始就限制进食量,使其体重到13周时达250g左右(此组模拟给最高剂量受试药物组动物的体重变化);Ⅲ组自由进食,待体重达250g左右时,再限制进食量,使其体重在第13周时稳定于250g左右;Ⅳ组开始时自由进食,使其体重达320g左右,再限制进食量,使其到第13周时体重为250g左右。Ⅲ和Ⅳ组是模拟试验开始时体重增长不受影响,然而使其生长保持稳定,或
In subacute and chronic toxicity tests, the absolute or relative weight of certain vital organs (also known as organ weight to body weight ratio or organ coefficient) is often used to indicate the effect of the test drug on animals, but when the test is completed, Group animals were significantly lower body weight than the control group, then there are some problems. First, we must distinguish between organ weight change is directly due to the test drug caused, or due to reduced food intake, for which the author made a simulation test to observe the effects of insufficient feeding on organ weight. Weight 110g male rats were divided into five groups: group I free to eat for 13 weeks, the final weight of 366g or so, Ⅱ group from the beginning to limit the amount of food intake, weight to 13 weeks up to 250g (this group simulated to the highest dose by Test group of animals weight changes); group Ⅲ free to eat until the body weight of 250g or so, and then limit the amount of food, so that the body weight at week 13 stabilized at about 250g; Ⅳ group free to eat at the beginning of the body weight 320g or so, and then limit the amount of food, so that by the thirteenth week when the weight is about 250g. Groups III and IV were unaffected by weight gain at the start of the simulations, leaving their growth stable, or