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目的 通过对有效持续气道正压 (CPAP)治疗前和治疗中阻塞性睡眠呼吸暂停综合征(OSAS)患者的睡眠脑电功率谱进行分析 ,了解CPAP治疗对大脑电活动的影响。方法 2 6例OSAS患者均经多导睡眠图 (PSG)监测确诊。通过快速傅立叶转换 ,计算C3 /A2 导联脑电图的边缘频率 (SEF)、中心频率 (MPF)、α、β、δ、θ指数 ,比较治疗前和CPAP治疗中睡眠结构以及上述参数的变化。 结果 经CPAP治疗可以显著降低睡眠中的睡眠呼吸紊乱指数和改善睡眠结构。慢波睡眠的缺乏比率由 19/ 2 6降为 10 / 2 6 (P =0 0 2 5 )。快速动眼睡眠 (REM)次数由 1 81± 0 2 5增至 2 6 5± 0 17(P =0 0 2 3) ;慢性睡眠占总睡眠时间 (TST)的比率由 (2 9± 1 1) %增至 (6 0± 1 2 ) % ,(P =0 0 43)。REM占TST的比率由(12 0± 1 7) %增至 (2 1 1± 1 6 ) % (P =0 0 0 1) ;Ⅰ、Ⅱ期睡眠占TST的比率由 (85 1± 2 1) %降至 (73 0± 1 9) % ,(P =0 0 ) ;入睡后清醒次数由 (12 2± 1 3)次降为 (9 4± 1 0 )次 (P =0 0 33)。Ⅰ、Ⅱ期浅睡眠次数由 (4 6 4± 4 2 )次降为 (36 7± 2 4)次 ,Ⅰ、Ⅱ期睡眠次数比较差异无显著性 (P =0 0 5 1)。总睡眠期、Ⅰ、Ⅱ期、REM睡眠的平均SEF分别从 (14 4± 0 4)Hz、(15 4± 0 4)Hz、(13 7±
Objective To investigate the effects of CPAP on brain electrical activity in patients with obstructive sleep apnea syndrome (OSAS) before and during CPAP. Methods Twenty-six OSAS patients were diagnosed by polysomnography (PSG). The EDF, center frequency (MPF), α, β, δ, θ index of C3 / A2 lead were calculated by Fast Fourier Transform, and the change of sleep structure and the above parameters before and after CPAP treatment were compared . Results CPAP treatment can significantly reduce sleep disordered breathing index and improve sleep structure. The lack of rate of slow wave sleep decreased from 19/26 to 10/26 (P = 0 0 2 5). The number of rapid eye movement sleep (REM) increased from 1 81 ± 0 25 to 2 6 5 ± 0 17 (P = 0 0 2 3). The ratio of chronic sleep to total sleep time (TST) was increased from (2 9 ± 1 1 )% To (6 0 ± 1 2)%, (P = 0 0 43). The ratio of REM to TST was increased from (12 0 ± 1 7)% to (2 1 1 ± 1 6)% (P = 0 0 01). The ratio of sleep in stage I and II to TST was (85 1 ± 2 1 ) Decreased to (73 0 ± 1 9)%, (P = 0 0), and the number of awake after falling asleep decreased from (12 2 ± 1 3) to (9 4 ± 1 0) times (P 0 0 33) . The number of shallow sleep in Ⅰ and Ⅱ decreased from (464 ± 42) to (36 7 ± 2 4) times. There was no significant difference in the number of sleep between Ⅰ and Ⅱ (P = 0 051). The mean SEF of total sleep, stage I, stage II, and REM sleep varied from (14 4 ± 0 4) Hz, (15 4 ± 0 4) Hz, (13 7 ±