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目的 :探讨术中动脉内化疗的临床应用。方法 :对实验组 11例口腔癌 (9例舌癌 ,2例口底癌 )患者行联合根治术及皮瓣修复术 ,氮芥术中舌动脉内给药 (浓度为 1mg/ml,剂量为 5mg) ,对照组 16例口腔癌 (13例舌癌 ,3例口底癌 )患者仅行手术 ,并同期行皮瓣修复。术后观察患者全身和局部反应并作近期随访。结果 :实验组无明显全身及局部反应 ,11例皮瓣全部存活 ,近期随访 (3～ 12月 ) ,实验组局部复发率为 9 1% (1/ 11) ,对照组为 18 8% (3/ 16 )。结论 :术中一次性动脉内化疗不影响皮瓣存活 ,临床不良反应小 ,可望减少局部复发 ,是一种治疗口腔鳞癌的有效辅助手段。
Objective: To investigate the clinical application of intra-arterial chemotherapy. Methods: 11 cases of oral cancer (9 cases of tongue cancer, 2 cases of mouth cancer) in the experimental group were treated with combined radical mastectomy and flap repair. Tongue intra-arterial administration of nitrogen mustard (concentration 1 mg / ml, In the control group, 16 cases of oral cancer (13 cases of tongue cancer and 3 cases of oral floor cancer) underwent surgery only and the flap was repaired in the same period. Postoperative patients were observed systemic and local reactions and for the recent follow-up. Results: There were no systemic and local reactions in the experimental group. All the 11 cases survived. The recent follow-up (3-12 months) showed that the local recurrence rate was 91% (1/11) in the experimental group and 18.8% (3) in the control group / 16). Conclusion: One-time intra-arterial chemoembolization does not affect the survival of the flap, and the clinical adverse reaction is small, and it is expected to reduce the local recurrence. It is an effective adjuvant for the treatment of oral squamous cell carcinoma.