论文部分内容阅读
IT-066化学名为3-AMINO-4-[4-[4-(1-PIPERI-DINOMEHYL)-2-PYRIDYLOXY]-CIS-2-BUTENY-LAMINO]-3-CYCLOBUTEN-1,2-DIONE·HCL,结构式是: HCl C_(19)H_(24)N_4O_3,HCl IT-066是大正制药株式会社,开发研制的一个新型H_2受体阻断剂。该药在豚鼠心房上的研究表明,可选择性地作用于H_2受体,是一个强效、持续性的H_2受体阻断药。在大鼠的离体和整体研究中表明,IT-066可有效持续地抑制胃酸分泌,并能抑制化学物质对胃和十二指肠粘膜的损伤。在冷刺激并用消灭痛处理的大
IT-066 has a chemical name of 3-AMINO-4- [4- [4- (1-PIPERI-DINOMEHYL) -2-PYRIDYLOXY] -CIS- 2-BUTENY-LAMINO] -3-CYCLOBUTEN-1,2-DIONE · HCL, structural formula is: HCl C_ (19) H_ (24) N_4O_3, HCl IT-066 is a new type of H_2 receptor blocker developed by Taisho Pharmaceutical Co., Ltd. The drug in guinea pig atrial studies have shown that selectively acting on the H 2 receptor, is a potent, sustained H 2 receptor blocker. In vitro and in vivo studies in rats have shown that IT-066 can effectively and continuously inhibit gastric acid secretion, and can inhibit the chemical substances on the stomach and duodenal mucosa damage. Stimulated in the cold and treated with the elimination of pain